![]() Pericyte-poor neovascular units have been shown to be more susceptible to one type of treatment (anti-VEGF agents) than pericyte-rich ones. This study provided ultrastructural electron microscopic support to the hypothesis that PIC is an inflammatory disease, with the inflammation originating in the choroid. Light and electron microscopy of the CNVM showed lymphocytes at the level of the inner choroid with sparing of the choriocapillaris. Ī recent pathological study examining choroidal neovascular membranes (CNVMs) secondary to PIC showed some intriguing findings. Subretinal neovascular membranes in this condition occur in between 40 to 75% of cases depending on case examined. They progress to atrophic scars, leaving a halo of depigmentation and are deeper and appear punched-out. They are bilateral in 80% of cases but are usually asymmetric. īilateral white-yellow chorioretinal lesions usually 100-200 microns diameter develop at the level of the inner choroid and retinal pigment epithelium (RPE) which rarely extend to the midperiphery and are never associated with vitritis. In the original case series by Watzke et al, myopia ranged from -3.25 to - 10.0 Diopters. It predominantly occurs in myopic females (90%), usually aged 18 to 40 years of age although more recent studies have reported a slightly different spectrum with mean age of presentation in one case series reported to be 32 years with a range of 24 to 52 years. Other studies have reported an association between PIC and HLA -DR2 and indeed there have been reports of familial cases such as in a mother-daughter cohort. Recent reports have also reported haplotype associations between MFCPU and PIC, given their similar genetic associations with IL10 and TNF loci. N MFC and Epstein- Barr (EB) virus infection, because patients with MFC had higher EB antibody titers for the early antigens. A subfoveal CNV membrane with hyperpigmented borders is seen. A previous study suggested an association betweeĬolor photograph demonstrates multiple, small, yellowish punctate lesions at the level of the choroid. Other theories have proposed an inflammatory or infectious thrombosis of the choriocapillary layer by an unidentified organism. ![]() PIC was proposed to be a variant of multifocal choroiditis and panuveitis (MFCPU), a form of limited myopic degeneration or a variant of Multifocal Choroiditis (MFC). The etiology has remained unclear with a wide spectrum of theories proposed. Punctate inner choroidopathy (PIC) is an idiopathic inflammatory disorder of the choroid which was first described by Watzke et al in 1984. ICD10: H30.1 Disseminated chorioretinal inflammation.ICD10: H30.9 Chorioretinal inflammation, unspecified.ICD9: 363.20 chorioretinitis, unspecified.3.2.2 Intraocular corticosteroid implants and injections. ![]()
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